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目的探讨三阴性乳腺癌临床病理特征及其预后成效分析。方法选择乳腺癌患者90例,依照免疫组织学法检测结果,将其分为观察组(三阴性乳腺癌)与对照组(非三阴性乳腺癌),每组45例。回顾性分析患者的临床资料,统计年龄、病理类型、组织学分级等。随访6年跟,统计预后情况。结果两组患者的年龄与肿瘤分期差异未见统计学意义(P>0.05);观察组病理类型为髓样癌、组织学分级为Ⅲ级者所占比例高于对照组(P<0.05);经过6年随访,观察组的复发率为24.4%,高于对照组(8.9%),无肿瘤生存率75.6%,低于对照组(91.1%),差异有统计学意义(P<0.05)。结论三阴性乳腺癌的的病理类型与组织学分级均与非三阴性乳腺癌有较大差别,较容易发生部分复发与远处转移,预后效果不佳,需加强检测分子标记物,并且尽早治疗,使生存率提高。
Objective To investigate the clinicopathological features and prognosis of triple negative breast cancer. Methods 90 patients with breast cancer were selected and divided into observation group (triple negative breast cancer) and control group (non triple negative breast cancer) according to the results of immunohistochemistry, with 45 cases in each group. Retrospective analysis of the clinical data of patients, statistical age, pathological type, histological grading. Follow-up with 6 years, the prognosis of the situation. Results There was no significant difference in age and tumor stage between the two groups (P> 0.05). The pathological type of the observation group was medullary carcinoma, and the histological grade was higher than that of the control group (P <0.05). After 6 years of follow-up, the recurrence rate of the observation group was 24.4%, higher than that of the control group (8.9%), with no tumor-free survival rate of 75.6% and lower than that of the control group (91.1%), the difference was statistically significant (P <0.05). Conclusion The pathological types and histological grade of triple-negative breast cancer are different from those of non-triple negative breast cancer. They are more likely to have partial recurrence and distant metastasis with poor prognosis. The detection of molecular markers should be strengthened and early treatment , So that the survival rate increased.