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目的介绍阳离子转运体1(OCT1)的底物、抑制剂和基因多态性研究与临床应用的研究现状,为其深入研究遗传药理学以及基础医学转化临床应用奠定基础。方法查阅国外有关文献,进行整理和归纳。结果与结论研究发现多种药物确是OCT1的潜在底物、抑制剂,且OCT1的基因多态性对其经典底物二甲双胍的药动学产生较大影响,这对OCT1的遗传药理学研究有重大的科学价值,为从OCT1基因遗传药理学的基础医学向临床应用转化提供方向。
Objective To introduce the research status of substrate and inhibitor and gene polymorphism of cationic transporter 1 (OCT1) and its clinical application, and lay a foundation for its further study on genetic pharmacology and clinical application of basic medical transformation. Methods Access to foreign literature, to organize and summarize. RESULTS AND CONCLUSIONS The study found that many kinds of drugs are indeed potential substrates and inhibitors of OCT1, and the gene polymorphism of OCT1 has a great influence on the pharmacokinetics of its classic substrate metformin. This study of the genetic pharmacology of OCT1 Significant scientific value, for the OCT1 genetic pharmacogenetics of basic medicine to clinical application of conversion direction.