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背景:利用胸部放射学检查和痰涂片检查手段对中学生进行肺结核病例筛检。目的:调查中学生中结核分枝杆菌的传播情况。设计:对从中学生肺结核病例分离出的结核分枝杆菌进行限制性酶切片段长度多态性(RFLP)图谱分析。结果:筛检发现的中学生病例存在簇状分布现象。在本研究中,一株具有独特RFLP图谱的结核杆菌分离频率最高。该菌株在1995年全国结核病患病率调查中也是最常见的临床分离结核分枝杆菌。该菌株似乎是韩国分布最广的结核杆菌株,编号为K1。经过对RFLP图谱的仔细研究,发现有34株临床分离菌株的RFLP图谱与K1株相似。因此,K1株和K1相关株(占总菌株的18.4％,命名为K系)似构成韩国目前的优势结核分枝杆菌株。结论:筛检发现的中学生病例存在簇状分布现象。K系结核杆菌是临床分离菌株中的最常见型别。
Abstract BACKGROUND: Thoracic radiography and sputum smear tests are used to screen the TB cases among middle school students. Objective: To investigate the spread of Mycobacterium tuberculosis among middle school students. DESIGN: Restriction fragment length polymorphism (RFLP) pattern analysis of Mycobacterium tuberculosis isolated from secondary TB cases. Results: There were clustered distribution of secondary school students in screening. In this study, the highest frequency of mycobacterium tuberculosis was isolated from a single RFLP map. This strain was also the most commonly clinically isolated Mycobacterium tuberculosis in the 1995 national tuberculosis prevalence survey. This strain appears to be the most widely distributed Mycobacterium tuberculosis strain in Korea, numbered K1. After a careful study of the RFLP pattern, RFLP patterns of 34 clinically isolated strains were found to be similar to the K1 strain. Therefore, the K1 strain and the K1-related strain (18.4% of the total strains, designated K series) appeared to constitute the current dominant Mycobacterium tuberculosis strains in Korea. Conclusion: There are clusters of high school students in the screening. Mycobacterium tuberculosis K is the most common type in clinically isolated strains.