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文献证实,同时使用几种透皮促进剂将产生协同作用,促进盐酸吗啡在体外的透皮吸收。本文对一些透皮促进剂:氮酮(3％)、十四烷酸异丙醇酯(5％)、Sefsol-318(5％)、l-薄荷醇(5％)和乙醇(40％)对盐酸吗啡的在体外透皮吸收的影响作了研究,并联合使用一些有不同作用机理的透皮促进剂,以期找到理想的透皮促进剂。体外皮肤渗透性实验:平均体重150g、雄性裸鼠的整皮或去角质层的腹部皮肤分别被用来作皮样。实验时,小心地固定皮样在双室
The literature confirms that simultaneous use of several transdermal enhancers will produce synergistic effects and promote transdermal absorption of morphine hydrochloride in vitro. Some of the transdermal enhancers: Azone (3%), Myristic Acid Isopropylate (5%), Sefsol-318 (5%), l- Menthol (5%), and Ethanol The effects of morphine hydrochloride on transdermal absorption in vitro were studied, and some transdermal enhancers with different mechanism of action were used together to find the ideal transdermal enhancer. In Vitro Skin Permeability Test: An average body weight of 150 g was applied to the skin of the abdomen of the intact or exfoliated layer of male nude mice, respectively. Experiment, carefully fixed dermatome in double chamber