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目的探讨高压氧对预防急性一氧化碳中毒迟发性脑病的可行性。方法对112例中重度急性一氧化碳中毒患者行高压氧治疗者(HBO组),对比未高压氧舱治疗的96例急性中重度一氧化碳中毒患者经常规治疗者(对照组),并对临床资料进行分析总结。结果 HBO组总有效率94.64%,对照组总有效率72.92%,两组疗效差异具有显著性(P<0.05);迟发性脑病发生率HBO组5.36%,对照组22.92%,两组发生率差异具有显著性(P<0.05)。结论高压氧治疗急性一氧化碳中毒可明显降低迟发性脑病发生。
Objective To investigate the feasibility of hyperbaric oxygen in preventing delayed encephalopathy after acute carbon monoxide poisoning. Methods One hundred and twelve patients with moderate to severe acute carbon monoxide poisoning underwent hyperbaric oxygen therapy (HBO group), compared with the conventional treatment group (control group) of 96 patients with moderate to severe carbon monoxide poisoning who were not treated with hyperbaric oxygen chamber. The clinical data were analyzed to sum up. Results The total effective rate was 94.64% in HBO group and 72.92% in control group, with significant difference between two groups (P <0.05). The incidence of delayed encephalopathy was 5.36% in HBO group and 22.92% in control group The difference was significant (P <0.05). Conclusion Hyperbaric oxygen treatment of acute carbon monoxide poisoning can significantly reduce the incidence of delayed encephalopathy.