功能失调性子宫出血(简称功血)是由于调节生殖的神经内分泌机制失常引起的异常子宫出血,而全身及内外生殖器官无器质性病变存在,其中50%发生于绝经过渡期。绝经过渡期功血的药物治疗效果差,部分患者因反复出血或严重贫血行子宫切除。近年研究发现,小剂量米非司酮治疗这一类型的功血效果良好,但其具体作用机制尚不十分清楚。现将米非司酮在绝经过渡期功血中的临床应用及其作用机制进行综述。 Dysfunctional uterine bleeding (referred to as dysfunctional uterine bleeding) is due to abnormal reproductive endocrine mechanisms cause abnormal uterine bleeding, and systemic and internal and external reproductive organs without organic disease, of which 50% occurred in the menopausal transitional period. Menopausal transitional dysfunctional blood drug treatment is poor, some patients due to repeated bleeding or severe anemia, hysterectomy. Recent studies have found that low-dose mifepristone treatment of this type of dysfunctional uterine bleeding effect is good, but its specific mechanism of action is not yet clear. Now mifepristone in the menopausal transitional blood in the clinical application and its mechanism of action are reviewed.