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目的探索米非司酮治疗绝经过渡期功能失调性子宫出血的新途径。方法58例确诊为绝经过渡期功能失调性子宫出血的患者,口服米非司酮10mg,1次/d,连服3个月。观察月经情况、子宫大小、内膜厚度,激素水平。结果全部患者治疗期间均闭经,停药后随访半年,其中13例直接进入绝经期,23例月经稀发,22例月经恢复正常。58例患者治疗后E2和P平均浓度较用药前明显下降,FSH、LH变化不明显。结论米非司酮治疗围绝经期功血有效,复发率低,不良反应小,是目前比较理想的药物治疗方案。
Objective To explore a new way for mifepristone to treat dysfunctional uterine bleeding during menopause. Methods 58 patients diagnosed as dysfunctional uterine bleeding in patients with menopausal transitional period, oral mifepristone 10mg, 1 / d, and even for 3 months. Menstrual conditions observed, the size of the uterus, endometrial thickness, hormone levels. Results All patients underwent amenorrhea during the treatment period. After stopping for six months, 13 cases went directly into menopause, 23 cases had menstruation, and 22 cases returned to normal. 58 patients after treatment, the average E2 and P concentrations were significantly lower than before treatment, FSH, LH did not change significantly. Conclusion Mifepristone is effective in treating peri-menopausal dysfunctional uterine bleeding with a low recurrence rate and small adverse reactions. It is an ideal drug treatment plan.