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目的:研究E-钙黏蛋白(E-cadherin)在浸润性乳腺癌中的表达情况,基于乳腺癌分子分型探讨其表达特点和临床病理意义。方法:应用免疫组织化学SP法检测87例浸润性乳腺癌中E-cadherin的表达情况。结果:E-cadherin在浸润性乳腺癌中呈现出高表达;E-cadherin的表达在浸润性乳腺癌分子分型之间具有统计学差异(P<0.05);E-cadherin在浸润性乳腺癌中的表达同组织学分级、淋巴结转移、病理类型和分子分型相关(P<0.05),同患者年龄、肿瘤大小和临床分期无关。结论:E-cadherin在浸润性乳腺癌分子分型中的差异性表达可能在浸润性乳腺癌的发生、发展和转移中发挥重要作用,可以作为乳腺癌诊断、治疗和预后判断的分子标记和分子分型的有益补充。
OBJECTIVE: To study the expression of E-cadherin in invasive breast cancer and to investigate its expression and clinicopathological significance based on molecular classification of breast cancer. Methods: Immunohistochemical SP method was used to detect the expression of E-cadherin in 87 cases of invasive breast cancer. Results: The expression of E-cadherin in invasive breast cancer was highly expressed. The expression of E-cadherin was significantly different between invasive breast cancer (P <0.05). The expression of E-cadherin in invasive breast cancer The expression was correlated with histological grade, lymph node metastasis, pathological type and molecular typing (P <0.05), but not with age, tumor size and clinical stage. Conclusion: The differential expression of E-cadherin in the molecular typing of invasive breast cancer may play an important role in the development, progression and metastasis of invasive breast cancer and may serve as a molecular marker and molecular marker for the diagnosis, treatment and prognosis of breast cancer A helpful supplement for typing.