哺乳动物精子顶体反应是自然受精起始过程中的重要环节,有多种精子膜蛋白和卵子透明带糖蛋白参与。这些蛋白一方面通过精子膜跨膜信号传导引起精子的顶体反应,另一方面,也为精子穿过透明带及精卵融合等提供必要的条件。精子顶体反应过程中涉及多种细胞信号传导的过程,如G蛋白耦联的信号传导、受体酪氨酸激酶(RTK)途径等。研究精子顶体反应过程中相关分子作用的信号传导通路,对进一步深入了解受精的分子机制具有重要的影响。 Mammal sperm acrosome reaction is an important part of the initial process of natural fertilization, a variety of sperm membrane protein and egg zona pellucida glycoprotein involved. On the one hand, these proteins cause the acrosome reaction of sperm through the transmembrane signal transduction of sperm membrane, on the other hand, they also provide the necessary conditions for the sperm to cross the zona pellucida and sperm-egg fusion. Sperm acrosome reaction involved in a variety of cell signaling processes, such as G protein-coupled signaling, receptor tyrosine kinase (RTK) pathway. The study of signal transduction pathways related to molecular action during acrosome reaction has a significant impact on the further understanding of the molecular mechanism of fertilization.