AIM:To evaluate the effect of early intrajejunal nutrition(EIN)on the natural course,entero-hormone secretion andits efficacy on dogs with acute pancreatitis.METHODS:An acute pancreatitis model was induced byinjecting 1 ml/kg of combined solution(2.5 % sodiumtaurocholate and 8 000-10 000 BAEE units trypsin/ml)intothe pancreas via pancreatic duct.Fifteen dogs were dividedinto parenteral nutrition(PN)group and EIN group.Twogroups were isonitrogenous and isocaloric.EIN was used atpostoperative 24 h.Serum glucose,calcium,amylase andlysosomal enzymes were determined before and 1,4,7 dafter acute pancreatitis was induced.All the dogs wereinjected 50 uCi ~(125)I-BSA 4 h before sacrificed on the 7~(th)day.The ~(125)I -BSA index of the pancreas/muscle,pancreas/blood,and pancreas pathology score(PPS)were determined.Theperipheral plasma cholecystokinin(CCK),secretin(SEC)andgastrin were measured by ELISA and RIA,and wasquantitative analysis of pancreatic juice and amylase,pancreatolipase and HCO_3~-,Cl~-,Na~+ and K~+ performed by anautochemical analyzer at 30,60,120 and 180 min afterbeginning PN or EIN on the first day.RESULTS:There was no difference between two groups inthe contents of serum calcium,amylase and lysosomalenzymes,~(125)I-BSA index of pancreas/muscle and pancreas/blood and PPS.The contents of CCK and gastrin in EIN werehigher than those in PN group at 60 and 120 min(P<0.05).The content of SEC post-infusion of nutrition solution washigher than that of pre-infusion of nutrition solution in bothgroups,and only at 60 min SEC in EIN group was higherthan that in PN group.The content of gastrin in EIN washigher than that in PN group at 120 and 180 min(P<0.05).The changes of pancreatic juice,amylase,pancreatolipaseand HCO_3~-,Cl~-,Na~+ and K~+ between two groups did notreach significantly statistical difference(P>0.05).CONCLUSION:EIN does not stimulate entero-hormone andpancreatic juice secretion,and enzyme-protein synthesis andrelease.EIN has no effect on the natural course of acutepancreatitis. AIM: To evaluate the effect of early intrajejunal nutrition (EIN) on the natural course, entero-hormone secretion andits efficacy on dogs with acute pancreatitis. METHODS: An acute pancreatitis model was induced by injection 1 ml / kg of combined solution (2.5% sodiumtaurocholate and 8 000-10 000 BAEE units trypsin / ml) intothe pancreas via pancreatic duct. Fifteen dogs were dividedinto parenteral nutrition (PN) group and EIN group.Twogroups were isonitrogenous and isocaloric. EIN was used at postponerative 24 h. Serum glucose, calcium, amylase andlysosomal enzymes were determined before and 1,4,7 dafter acute pancreatitis was induced. All the dogs were injected 50 μCi ~ (125) I-BSA 4 h before sacrificed on the 7 th day. -BSA index of the pancreas / muscle, pancreas / blood, and pancreas pathology score (PPS) were determined. Theperipheral plasma cholecystokinin (CCK), secretin (SEC) andgastrin were measured by ELISA and RIA, and wasquantitative analysis of pancreatic juice and amylase , pancreatolipase and HCO_3 ~ -, Cl ~ -, Na ~ + and K ~ + performed by anautochemical analyzer at 30, 60, 120 and 180 min afterbeginning PN or EIN on the first day .RESULTS: There was no difference between two groups inthe contents of serum calcium, amylase and lysosomalenzymes, ~ (125) I-BSA index of pancreas / muscle and pancreas / blood and PPS.The contents of CCK and gastrin in EIN werehigher than those in PN group at 60 and 120 min (P <0.05). content of SEC post-infusion of nutrition solution washigher than that of pre-infusion of nutrition solution in both groups, and only at 60 min SEC in EIN group was higherthan that in PN group. The content of gastrin in EIN washigher than that in PN group at 120 (P> 0.05) .CONCLUSION: EIN (P <0.05) and 180 min (P <0.05) .The changes of pancreatic juice, amylase, pancreatolipase and HCO_3 ~ -, Cl ~ -, Na ~ + K ~ + between two groups did notreach significant statistical difference does not stimulate entero-hormone and pancreatic juice secretion, and enzyme-protein synthesis and release. EIN has no effect on the natural ccourse of acute pancreatitis