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目的观察康复新液联合奥美拉唑、克拉霉素、甲硝唑治疗胃十二指肠球部溃疡临床疗效。方法将110例胃十二指肠球部溃疡患者随机分治疗组58例,口服康复新液10 ml、奥美拉唑20 mg、克拉霉素0.25 g、甲硝唑0.2g,均为2次/d,连服10 d;对照组52例,口服奥美拉唑20 mg、克拉霉素0.25 g、甲硝唑0.2 g,均为2次/d,连服10d。10 d后均复查胃镜及HP检测。结果治疗组愈合率93.1%,总有效率98.3%;对照组愈合率22.1%,总有效率73.1%。两组愈合率及总有效率差异有统计学意义(P<0.05)。HP根除率治疗组及对照组分别为96.6%和94.2%,不良反应率治疗组及对照组分别为5.2%和5.8%,HP根除率及不良反应率差异无统计学意义(P>0.05)。结论康复新液联合奥美拉唑、克拉霉素、甲硝唑治疗胃十二指肠球部溃疡疗效高,疗程短。
Objective To observe the curative effect of Kangfuxin solution combined with omeprazole, clarithromycin and metronidazole in the treatment of gastroduodenal ulcer. Methods A total of 110 patients with gastroduodenal ulcer were randomly divided into treatment group (58 cases), oral rehabilitation fluid (10 ml), omeprazole (20 mg), clarithromycin 0.25 g and metronidazole 0.2 g / d, even for 10 days; control group of 52 patients, oral omeprazole 20 mg, clarithromycin 0.25 g, metronidazole 0.2 g, were 2 times / d, and even served 10d. After 10 days were reviewed endoscopy and HP detection. Results The healing rate was 93.1% in the treatment group and the total effective rate was 98.3%. In the control group, the healing rate was 22.1% and the total effective rate was 73.1%. There was significant difference between the two groups in the healing rate and the total effective rate (P <0.05). HP eradication rate was 96.6% in the treatment group and 94.2% in the control group, respectively. The adverse reaction rate was 5.2% in the treatment group and 5.8% in the control group. There was no significant difference in the eradication rate and adverse reaction rate of HP between the two groups (P> 0.05). Conclusion Kangfuxin solution combined with omeprazole, clarithromycin and metronidazole in the treatment of gastroduodenal ulcer has high efficacy and short course of treatment.