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2007年3月至2008年6月鼻咽癌放疗后局部复发和(或)远处转移患者20例用吉西他滨1000mg/m2,d1、d8+生理盐水100ml静脉点滴30min完成;DDP20mg/m2+生理盐水250ml静脉滴注,d1～d4,21d为l个周期,治疗2～6个周期后评价其近期疗效。[结果]完全缓解(CR)2例,部分缓解(PR)12例,稳定(SD)6例,无病情进展(PD),总有效率(PR+CR)为70%(14/20);临床受益率(CBR)为100%(20/20)。主要毒副反应为骨髓抑制、恶心呕吐和肝功能损害。
From March 2007 to June 2008, 20 patients with local recurrence and / or distant metastasis after nasopharyngeal carcinoma were treated with gemcitabine 1000mg / m2, d1, d8 + 100ml intravenously for 30min; DDP20mg / m2 + saline 250ml Instillation, d1 ~ d4, 21d for l cycles, treatment of 2 to 6 cycles after the evaluation of its immediate effect. [Results] There were 2 cases of complete remission (CR), 12 cases of partial remission (PR), 6 cases of stable (SD), no progression of disease (PD) and the total effective rate was 70% (14/20). The clinical benefit rate (CBR) was 100% (20/20). The main side effects of bone marrow suppression, nausea and vomiting and liver damage.