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随着多重耐药性的恶性疟虫(plasmodium falciparum)的不断扩散,迫切需要开发新的抗疟疾药物。Enpiroline是一个新的抗疟疾药物,已证实它对氯奎宁敏感的或多重耐药性的恶性疟虫都有显著的活力。以恒河猴试验,对多重耐药性的恶性疟虫越南史密斯栋,单一口服Enpiroline磷酸盐,日剂量30毫克/公斤,连续3天,可治愈90%的动物;在人的试验里,Enpiroline磷酸盐对诱导的多重耐药性恶性疟虫越南史密斯株的感染也有效。为了鉴定氨基醇类抗疟疾制剂共同的空间和结构特点,以便设计更为有效的药物和
With the proliferation of multi-drug resistant plasmodium falciparum, there is an urgent need to develop new antimalarial drugs. Enpiroline, a new anti-malaria drug, has been shown to have significant activity against chloroquine-sensitive or multi-drug resistant Plasmodium falciparum. In a rhesus monkeys trial, a single oral dose of Enpiroline phosphate was administered orally to a multi-drug resistant Plasmodium falciparum at a dose of 30 mg / kg for three days in up to 90% of animals. In human trials, Enpiroline Phosphates are also effective in inducing infections with the multi-drug resistant Plasmodium vietnameseus strain. In order to identify the common spatial and structural characteristics of aminoalcoholic anti-malaria agents in order to design more effective drugs and