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目的了解药物治疗妊娠期甲状腺自身抗体阴性的亚临床甲减孕妇是否对母儿短期预后产生影响。方法选择从2011年8月-2013年10月复旦大学附属妇产科医院孕20周内筛查出的甲状腺自身抗体阴性的亚临床甲减单胎孕妇作为研究对象,根据药物治疗情况分为治疗组和未治疗组。研究期内治疗组有184例入组,未治疗组有179例入组。结果未治疗组有4例优生引产、1例自然流产。治疗组无流产和优生引产。两组孕妇妊娠结局如妊娠期糖尿病、妊娠期高血压疾病、胎盘早剥、前置胎盘、胎膜早破、胎窘、早产、低出生体重儿、巨大儿方面的组间差异无统计学意义。结论药物治疗妊娠期自身抗体阴性的亚临床甲减不具有改善母儿短期预后的价值。
Objective To understand whether drug treatment of subclinical hypothyroidism during pregnancy negative thyroid autoantibodies affect the short-term prognosis of maternal and child. Methods From August 2011 to October 2013 Fudan University Obstetrics and Gynecology Hospital screening of pregnant women within 20 weeks of thyroid autoantibodies negative subclinical hypothyroidism singleton pregnant women as the research object, according to the drug treatment is divided into treatment Group and untreated group. In the study period, 184 patients were enrolled in the treatment group and 179 patients in the untreated group. Results The untreated group had 4 cases of induced abortion and 1 case of spontaneous abortion. The treatment group had no abortion and eugenics. There were no significant differences between the two groups in terms of pregnancy outcome such as gestational diabetes mellitus, gestational hypertension, placental abruption, placenta previa, premature rupture of membranes, fetal distress, premature birth, low birth weight infants and macrosomia . Conclusion The subclinical hypothyroidism with drug-resistant autoantibodies in pregnancy does not improve the short-term prognosis of maternal and child.