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目的:分析血管形成素(angiogenin,ANG)在鼻咽癌(nasopharyngealcarcinoma,NPC)患者血循环的含量及其临床意义。方法:采用ELISA测定42例NPC患者(Ⅰ期4例,Ⅱ期20例,Ⅲ期11例,Ⅳ期7例)和30例健康人血清ANG水平。结果:NPC患者治疗前血清ANG水平为(371.4±123.5)ng/mL,显著高于健康对照组的(292.5±74.2)ng/mL(P<0.01),且血清ANG水平随着NPC临床分期的增加而升高(P<0.05);治疗后患者达到部分缓解或完全缓解,血清ANG水平为(340.6±112.4)ng/mL,比治疗前明显降低(P<0.05),但仍然高于健康对照组(P<0.05)。结论:NPC患者血清ANG水平上升,ANG升高程度与肿瘤的进展有关。
Objective: To analyze the blood circulation of angiogenin (ANG) in patients with nasopharyngeal carcinoma (NPC) and its clinical significance. Methods: The serum levels of ANG in 42 patients with NPC (4 in stage Ⅰ, 20 in stage Ⅱ, 11 in stage Ⅲ, 7 in stage Ⅳ) and 30 healthy controls were measured by ELISA. Results: The level of serum ANG was (371.4 ± 123.5) ng / mL in NPC patients before treatment, which was significantly higher than that in healthy controls (292.5 ± 74.2) ng / mL (P <0.01) (P <0.05). After treatment, the patients achieved partial or complete remission. The level of serum ANG was (340.6 ± 112.4) ng / mL, which was significantly lower than that before treatment (P <0.05), but still higher than that of healthy controls Group (P <0.05). Conclusion: The level of ANG in serum of patients with NPC increased and the degree of ANG increased with the progress of tumor.