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目的探讨有效治疗糖尿病周围神经病变的方法。方法于2003年6月至2005年9月,以美国密歇根神经病变临床筛查及记分分级(MDNS)方法为诊断标准,将68例糖尿病周围神经病变患者随机分为两组,对照组给控制血糖、肌注弥可保、静脉点滴脉络宁针30 mL 每日1次;治疗组,在对照组的基础上加用静脉点滴地奥黄芪针80 mL 每日1次、前列腺素 E1针100μg每日1次,两组均3周为一疗程。治疗前后评估MDNS 记分。结果治疗组与对照组治疗结果有显著性差异(P<0.005)。结论大剂量黄芪加前列腺素 E1联合治疗糖尿病周围神经病变可扩张外周血管、降低血黏度、抗血小板积聚明显改善糖尿病周围神经病变症状。
Objective To explore the effective treatment of diabetic peripheral neuropathy. Methods From June 2003 to September 2005, 68 patients with diabetic peripheral neuropathy were randomly divided into two groups according to the clinical screening and score-classification (MDNS) method of Michigan’s neuropathy. The control group was given blood glucose , Intramuscular injection of mecoprop, intravenous Mailuoning ningtang 30 mL once a day; treatment group, on the basis of the control group plus intravenous Dioscinus Astragalus 80 ml once daily, prostaglandin E1 needle 100μg daily 1 times, two groups were 3 weeks for a course of treatment. MDNS scores were assessed before and after treatment. Results There was significant difference between the treatment group and the control group (P <0.005). Conclusion Combined treatment of high dose of astragalus plus prostaglandin E1 in diabetic peripheral neuropathy can expand peripheral blood vessels, reduce blood viscosity, anti-platelet aggregation significantly improve the symptoms of diabetic peripheral neuropathy.