论文部分内容阅读
目的:研究胃腺癌局部淋巴结中树突状细胞(DC)对转移和预后的影响。方法:将S-100蛋白作为DC特异性标记物,应用S-P免疫组化方法检测胃腺癌局部淋巴结中DC的数量和分布。结果:转移组淋巴结中DC较非转移组明显减少。在57例转移组中,DC显著者18例,5年生存率55.56％;不明显者39例,5年生存率23.08％。30例非转移组中,DC显著者19例,5年生存率73.68％;不明显者11例,5年生存率36.36％。经x~2检验,在上述两组中,DC显著者的转移和5年生存率与不明显者的差异均有显著性意义(P<0.05)。结论:胃腺癌局部淋巴结中DC程度同转移和预后密切相关。
Objective: To study the effect of dendritic cells (DCs) on the metastasis and prognosis of gastric adenocarcinoma with local lymph nodes. Methods: S-100 protein was used as a DC-specific marker. The number and distribution of DCs in gastric adenocarcinoma of the local lymph nodes were detected by S-P immunohistochemistry. Results: The lymph node metastasis in the metastasis group was significantly lower than the non-metastasis group. Among the 57 cases of metastasis, 18 cases were significant DC, the 5-year survival rate was 55.56%, 39 cases were not obvious, and the 5-year survival rate was 23.08%. In 30 cases of non-metastasis group, there were 19 cases with significant DC, the 5-year survival rate was 73.68%, 11 cases were not obvious, and the 5-year survival rate was 36.36%. After x ~ 2 test, in the above two groups, significant differences were found in the metastasis of the significant DC and the 5-year survival rate between the two groups (P <0.05). Conclusion: The degree of DC in gastric adenocarcinoma is closely related to the metastasis and prognosis.