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西沙必利(Cisapride)作用于胃肠道器官壁内肌神经丛神经节后末梢,具有促使壁肌释放乙酰胆碱,刺激消化系统器官,增进食管、胃、肠道运动的功能。西沙必利为瑞典Jessen制药公司生产。临床应用于胃、食管反流症:各种疾病和药物引起的胃排空迟缓;非溃疡性消化不良及胃肠运动功能失调引起的慢性特发性消化不良、便秘与假性阻塞。不良反应发生率不足3％,主要为腹部痉挛、腹痛、腹泻、肠鸣。偶见头晕、恶心、头痛等。
Cisapride acts on the posterior terminal of the plexus pectoralis muscle of the gastrointestinal tract organ, and has the function of releasing acetylcholine, stimulating digestive system organs and promoting esophageal, gastric and intestinal motility. Cisapride is manufactured by Swedish Jessen Pharmaceuticals. Clinical application in the stomach, esophageal reflux disease: various diseases and drugs caused by gastric emptying; non-ulcer dyspepsia and gastrointestinal motility disorders caused by idiopathic dyspepsia, constipation and pseudo-obstruction. The incidence of adverse reactions less than 3%, mainly abdominal cramps, abdominal pain, diarrhea, bowel. Occasionally dizzy, nausea, headache and so on.