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目的：比较茵栀黄口服液和亿活治疗新生儿高胆红素血症的临床疗效。方法选取2012年1月—2015年1月天津市第一中心医院收治的200例新生儿高胆红素血症患儿，根据治疗方法不同分为对照组和观察组，各100例。观察组给予蓝光照射联合茵栀黄治疗，对照组给予蓝光照射联合亿活治疗。比较两组患儿治疗前后血清总胆红素（TBIL）水平、住院时间、光疗时间、日均胆红素下降值及临床疗效。结果治疗前、后两组患儿血清 TBIL 水平比较，差异无统计学意义（P ﹥0.05）。治疗后，两组患儿血清 TBIL 水平均较治疗前下降，差异有统计学意义（P﹤0.05）。两组患儿住院时间、光疗时间及总有效率比较，差异无统计学意义（P ﹥0.05）。观察组日均胆红素下降值大于对照组，差异有统计学意义（P ﹤0.05）。两组患儿不良反应发生率比较，差异无统计学意义（P ﹥0.05）。结论茵栀黄口服液治疗新生儿高胆红素血症的疗效略优于亿活。“,”Objective To compare the effect of Yinzhihuang oral liquid and Bioflor in treating newborn hyperbilirubi-nemia. Methods A total of 200 newborns with hyperbilirubinemia was chosen in the First Central Hospital of Tianjin from Jan-uary 2012 to January 2015,according to the different treatment method they were divided into control group(100 cases)and ob-servation group(100 cases). Observation group was given blue light irradiation treatment and Yinzhihuang oral liquid,control group was given blue light irradiation treatment and Bioflor. The serum total bilirubin(TBIL)before and after treatment,the time of hospitalization,the time of blue light irradiation treatment and the total effective rate between the two groups were com-pared. Results The TBIL levels before and after treatment showed no significant differences between the two groups( P ﹥0. 05). After treatment the TBIL levels of two groups were lower than before treatment(P ﹤ 0. 05). The hospitalization time, the time of blue light irradiation treatment and the total effective rate showed no significant differences between the two groups(P﹥ 0. 05). The serum bilirubin levels declined everyday of observation group were greater than those of control group( P ﹤0. 05). Occurrence rate of adverse reaction showed no significant differences between the two groups(P ﹥ 0. 05). Conclusion The effect of Yinzhihuang oral liquid is better than Bioflor in the treatment of newborn hyperbilirubinemia.