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目的：探讨含呋喃唑酮序贯疗法在幽门螺杆菌（Helicobacter pylori，Hp）根除失败后的补救治疗中的疗效及安全性。方法选取碳14尿素呼气试验(14C-UBT)阳性或经胃镜快速尿素酶检测Hp阳性病例80例，均为三联疗法（质子泵抑制剂＋2种抗生素）治疗无效或复发的病例。随机分为两组各40例，治疗组为序贯疗法，对照组为传统四联疗法，疗程均为10 d。治疗后1个月进行14C-UBT检测。结果两组之间Hp根除率（85.0%vs87.5%）无统计学差异（P＞0.05）。但治疗组患者依从性好，不良反应明显低于对照组（P＜0.05）。结论含呋喃唑酮序贯疗法与传统四联疗法在 Hp根除失败后的补救治疗中疗效均好，但含呋喃唑酮序贯疗法不良反应明显少，患者依从性好而安全可靠。“,”Objective to evaluate the containing furazolidone sequential therapy in Helicobacter pylori to eradicate the ef icacy and safety of remedial treatment after failure. Methods select carbon 14 urea breath test (14 c UBT), or by gastroscope rapid urease test Hp positive cases 80 cases, are the triple therapy (proton pump inhibitors + 2 kinds of antibiotic treatment is invalid or recurrence of cases. Randomly divided into two groups (40 cases, the treatment group as the sequential therapy, compared with the traditional quadruple therapy, a course of 10 days. 1 month after treatment for 14 c - UBT detection. Results Hp eradicate rate between two groups (85.0% vs87.5 %), no statistical dif erence (P> 0.05). But the treatment group patients compliance is good, adverse reactions obviously lower than the control group (P<0.05). Conclusion with furazolidone sequential therapy and traditional quadruple therapy in Hp eradication failure after remedial treatment curative ef ect is good, but with less adverse reaction obviously furazolidone sequential therapy, the patients compliance is good and safe and reliable.