药物对映体的人体药效学差异巴比妥类(Barbiturates):(+)巴比妥类可引起中枢神经兴奋,而(-)巴比妥类则为镇静剂。例如,戊巴比妥以外消旋体供售,但右旋体伴有速激过敏(打呃和不随意痉挛)以及在恢复期出现强的精神症状。在早期临床试验中亦观察到,美索比妥(Methohexital)运动神经不良作用(打呃和四肢痉挛)约占病例的40%。美索比妥含有两个不对称碳原子,最初使用的是含有4个立体异构体的混合物。通过对这些异构 Human Pharmacodynamic Differences in Drug Enantiomers Barbiturates: (+) Barbiturates can cause central nervous excitement, while (-) barbiturates are sedatives. For example, pentobarbital is marketed as a racemate, but dextral sufferers have hypersensitivity (hiccups and involuntary spasms) and severe psychiatric symptoms during the recovery phase. In early clinical trials, it was also observed that motor neuropathic effects (hitting and extremity spasms) of Methocetital account for about 40% of cases. Methoxetine contains two asymmetric carbon atoms, originally used as a mixture of four stereoisomers. Pass these isomerism