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自从1969年Olney 首次报道非肠道注射大剂量谷氨酸(Glutamic acid,Glu)破坏新生期小鼠下丘脑弓状核以来,相继发现许多其他内源性兴奋性氨基酸及其结构类似物也有损毁脑细胞的神经毒性作用。这些化合物总称兴奋性毒素(Excitotoxins,ET)。近年来,ET作为化学损毁脑内特定部位的工具药在确定脑的功能定位和复制人类神经系统疾病的动物模型方面已获得广泛的应用。同时,对ET 本身作用机理的研究也正在成为神经/精神病理学
Since Olney first reported in 1969 that large doses of glutamine (Glutamic acid, Glu) were parenterally destroyed hypothalamic arcuate nuclei in neonatal mice, many other endogenous excitatory amino acids and their structural analogues were also found to be damaged Neurotoxicity of brain cells. These compounds are collectively called Excitotoxins (ET). In recent years, ET has been widely used as a tool for chemically damaging specific parts of the brain in animal models that determine the functional location of the brain and replicate the diseases of the human nervous system. At the same time, research on the mechanism of action of ET itself is also becoming neuropsychopathology