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已知由T 细胞产生的淋巴因子提高了巨噬细胞对分枝杆菌的杀菌能力,尤其是γ干扰素(IFNγ)是此作用中主要的T 淋巴细胞产物。以前的研究提示体内胸腔积液T 淋巴细胞应答结核抗原时产生IFNγ比外周血细胞高,但未见报道。本文作者利用固相RIA 法测定了不同病因的80例胸腔积液(30例结核性;20例恶性及30例非结核性)的胸水及血清中IFNγ水平,同时检测了胸水及外周血淋巴细胞总数及T 细胞亚群(OKT_3、OKT_4和OKT_8的百分率和绝对值。结果表明各组胸水中T_3和T_4淋巴细胞的百分率及T_4/T_8比率较外周血高。结核性胸水T_3和T_4淋巴细胞的绝对值显著高于恶性(P<0.001)和非结核性胸水组(P<0.001)。结核性胸水中IFNγ水平(平均91.2U/ml,中值55U/ml.范围2,3～413U/
Lymphokines, which are known to be produced by T cells, enhance the bactericidal activity of macrophages against mycobacteria, and in particular gamma interferon (IFN gamma) is a major T lymphocyte product in this action. Previous studies have suggested that IFNγ production in peripheral blood from patients with pleural effusion T lymphocytes is higher than that of peripheral blood cells in response to tuberculosis antigens, but no reports have been reported. The authors used solid-phase RIA method to determine pleural effusion and serum IFNγ levels in 80 cases of pleural effusion (30 cases of tuberculous; 20 cases of malignant and 30 cases of non-tuberculous) with different etiology, and the detection of pleural fluid and peripheral blood lymphocytes T lymphocyte subsets and T cell subsets (OKT_3, OKT_4 and OKT_8) .The results showed that the percentage of T 3 and T 4 lymphocytes and the ratio of T 4 / T 8 in pleural effusion were higher than that in peripheral blood in each group The absolute value of tuberculous pleural effusion was significantly higher than that of malignant (P <0.001) and non-tuberculous pleural effusion (P <0.001) .The levels of IFNγ in tuberculous pleural effusion (average 91.2U / ml, median 55U /