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新型降压药物简介β受体阻滞剂自1967年临床应用后,5年内就迅速成为最常用的抗高血压药。品种很多,药理特性各异。但作为抗高血压、抗心绞痛和抗心律失常药物,临床疗效大致相似。降压机理可能是作用于中枢神经系统或周围组织的突触前β受体,从而减少心排出量,降低血浆肾素活性。各种β阻滞剂在心脏选择性、内在拟交感活性以及膜稳定作用等方面虽有差别,但临床价值不大
New antihypertensive drugs profile β blockers since 1967 clinical application, within 5 years quickly became the most commonly used antihypertensive drugs. Many varieties, different pharmacological properties. However, as antihypertensive, anti-angina and anti-arrhythmic drugs, the clinical effect is similar. The hypotensive mechanism may be acting on the presynaptic β receptors in the central nervous system or in the surrounding tissues, thereby reducing cardiac output and decreasing plasma renin activity. Various beta blockers in cardiac selectivity, the intrinsic sympathomimetic activity and membrane stabilization and other aspects although there are differences, but the clinical value is not large