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观察比较了毒毛旋花子甙Ｋ（０．２３ｍｇ／ｋｇ，ｉｖ）对戊巴比妥钠和维拉帕米所致家兔整体心衰模型的拮抗作用和毒毛旋花子甙Ｋ（０．３１ｍｇ／ｋｇ，ｉｖ）对两模型组的毒性反应。比较毒毛旋花子甙Ｋ对两种心衰模型的拮抗作用和毒性反应的差异。结果表明：毒毛旋花子甙Ｋ（０．２３ｍｇ／ｋｇ，ｉｖ）对戊巴比妥钠组的作用强于维拉帕米组。毒毛旋花子甙Ｋ（０．３１ｍｇ／ｋｇ，ｉｖ）在戊巴比妥钠组出现了毒性反应，而在维拉帕米组则未出现。结果提示，维拉帕米所致心衰模型对强心甙的正性肌力作用反应不够敏感，同时还可阻止强心甙毒性反应的出现，因此，此模型似乎不适于强心甙类药物的研究。
The antagonistic effects of Toxins K (0.23mg / kg, iv) on pentobarbital sodium and verapamil-induced global heart failure model and the toxicity of spinosad K (0. 31 mg / kg, iv) Toxicity to both model groups. To compare the antagonistic effects and toxicological responses of Venomoside K to two models of heart failure. The results showed that the toxicity of spinosad K (0.23 mg / kg, iv) to pentobarbital sodium group was stronger than that of verapamil group. Toxins K (0.31 mg / kg, iv) developed toxic effects in the sodium pentobarbital group but not in the verapamil group. The results suggest that verapamil-induced heart failure model is not sensitive to the positive inotropic effect of cardiac glycosides and may also prevent the occurrence of cardiac glycosides. Therefore, this model does not seem to be suitable for cardiac glycosides Research.