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目的研究血管紧张素Ⅱ1(AT1)受体自身抗体与原发性高血压(EH)的关系及干预疗效。方法收集140例EH患者血清,以合成的AT1受体多肽片段为抗原,用ELISA法检测EH患者及40例正常人血清中的AT1受体自身抗体,并比较氯沙坦和依那普利对抗体阳性的EH患者的疗效。结果140例难治性EH患者中抗AT1自身抗体阳性60例(42.8%),明显高于正常对照组(P<0.01),在EH组中,抗AT1受体自身抗体阳性患者用氯沙坦的降压效果明显高于依那普利。结论抗AT1受体自身抗体可能在EH的发病中发挥作用,在该抗体阳性的EH患者中,AT1受体拮抗剂可能有更好的效果。
Objective To study the relationship between the autoantibodies against angiotensin Ⅱ 1 (AT1) receptor and essential hypertension (EH) and the intervention effect. Methods Serum of 140 patients with EH were collected and the AT1 receptor peptide fragments synthesized were used as the antigen. The AT1 receptor autoantibodies in serum of EH patients and 40 normal persons were detected by ELISA, and losartan and enalapril EH-positive patients with EH efficacy. Results The anti-AT1 autoantibodies in 60 patients (42.8%) were significantly higher than those in the normal control group (P <0.01) in 140 refractory EH patients. In the EH group, anti-AT1 receptor autoantibodies were detected with losartan The antihypertensive effect was significantly higher than that of enalapril. Conclusion Anti-AT1 receptor autoantibodies may play a role in the pathogenesis of EH. In this antibody-positive EH patients, AT1 receptor antagonists may have a better effect.