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色甘酸钠(Sodium Cromoglycate)与盐酸麻黄素(Ephedrin Hydrochlorid)制成复方制剂,治疗过敏性鼻炎,临床观察表明该制剂有收缩血管、减轻鼻粘膜水肿,抗过敏作用,效果满意,未见不良反应。 1 仪器和试药 岛津UV—2100型紫外分光光度计;色甘酸钠原料由上海五洲药厂提供;盐酸麻黄素原料由新疆制药厂提供;甘油、枸橼酸钠等原料均为药用。 2 制备 2.1 处方 色甘酸钠2.0g,盐酸麻黄素0.5g,氯化钠0.9g,甘油2.Oml,枸橼酸钠0.4g,蒸馏水加至100ml。 2.2 制备方法 将色甘酸钠,盐酸麻黄素、氯化钠、甘油、枸橼酸钠等溶于适量蒸馏水中,搅拌,溶解,加蒸馏水至足量,搅拌均匀,过滤即得。 3 质量控制 3.1 性状 本品为无色透明溶液。 3.2 鉴别 色甘酸钠:按中国药典二部95版P238鉴别项下。 盐酸麻黄素;按中国药典二部95版P692鉴别项下。
Sodium Cromoglycate and Ephedrin Hydrochlorid can be used to treat allergic rhinitis. Clinical observation shows that the preparation has the properties of constricting blood vessels, alleviating nasal mucosa edema and antiallergic effect with satisfactory results and no adverse reactions . 1 Instruments and reagents Shimadzu UV-2100 UV spectrophotometer; cromolyn sodium raw materials provided by the Shanghai Wuzhou pharmaceutical; ephedrine hydrochloride raw materials provided by the Xinjiang Pharmaceutical Factory; glycerol, sodium citrate and other raw materials are medicinal. 2 Preparation 2.1 Prescription cromolyn sodium 2.0g, ephedrine hydrochloride 0.5g, sodium chloride 0.9g, glycerol 2. Oml, sodium citrate 0.4g, distilled water was added to 100ml. 2.2 Preparation cromolyn sodium, ephedrine hydrochloride, sodium chloride, glycerin, sodium citrate, etc. dissolved in distilled water, stirring, dissolved, add distilled water to a sufficient amount, stir, that is, filtered. 3 Quality Control 3.1 Traits This product is colorless and transparent solution. 3.2 Identification of cromolyn: According to the Chinese Pharmacopoeia 95 version P238 identification under. Ephedrine hydrochloride; according to the Chinese Pharmacopoeia 95 P62 Edition identification.