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目的研究癌胚抗原(CEA)、细胞角质蛋白(CYFRA21-1)和神经元特异性烯醇化酶(NSE)在肺鳞状细胞癌(SQC)患者血清中的水平与患者TNM分期、可否行手术治疗及预后之间的关系。方法检测210例SQC患者的血清标本(Ⅰ期20例、Ⅱ期27例、ⅢA期55例、ⅢB期80例、Ⅳ期28例)CEA、CYFRA 21-1和NSE的血清水平。NSE和CYFRA 21-1采用放免测定,CEA采用化学发光法测定。结果CYFRA 21-1升高最为常见。CEA和CYFRA 21-1与TNM分期相关,而NSE与TNM分期无关。CEA和CYFRA 21-1血清水平均值与可手术(1、Ⅱ、ⅢA)和不可手术(ⅢB、Ⅳ期)有相关性(P<0.001)。NSE血清水平均值与可否手术差异无显著性。结论治疗前CYFRA 21-1和NSE的血清浓度与预后有关,可作为SQC患者可否手术的参考指标,并可为SQC预后判断提供重要信息。
Objective To investigate the relationship between serum levels of carcinoembryonic antigen (CEA), cytokeratin (CYFRA21-1) and neuron specific enolase (NSE) in patients with lung squamous cell carcinoma (SQC) and TNM staging The relationship between treatment and prognosis. Methods The serum levels of CEA, CYFRA 21-1 and NSE in 210 SQC patients were detected by serum samples (20 in stage Ⅰ, 27 in stage Ⅱ, 55 in stage ⅢA, 80 in stage ⅢB and 28 in stage Ⅳ). NSE and CYFRA 21-1 using radioimmunoassay, CEA chemiluminescence method. Results CYFRA 21-1 increased the most common. CEA and CYFRA 21-1 are associated with TNM staging, whereas NSE is not associated with TNM staging. The mean serum levels of CEA and CYFRA 21-1 were correlated with operable (grade 1, II, IIIA) and inoperable (grade IIIB, IV) (P <0.001). There was no significant difference between NSE serum mean and surgical feasibility. Conclusions The serum concentration of CYFRA 21-1 and NSE before treatment is related to the prognosis and can be used as a reference index for the surgical treatment of patients with SQC and can provide important information for the prognosis judgment of SQC.