尽管用硝酸盐类治疗心绞痛已一个多世纪,但人们仍然不知道如何使用它们最有效。由于此药在肝脏代谢快和口服时个体间的吸收和代谢有很大的差异,每天需要多次使用。由于上述原因,生产了经皮释放的药膏,此药膏24小时以恒定速度释放硝酸甘油:约0.5mg/cm~2。此药膏已得到广泛接受,但也引起了争论:它们是否能维持24小时的稳定血浆浓度,在此期间临床上是否有作用以及是否出现耐受。 Although nitrates have been used to treat angina for more than a century, people still do not know how to use them most effectively. Because of its rapid metabolism in the liver and oral absorption and metabolism of individual differences are very large, need to be used more than once a day. For the above reasons, transdermally released ointments were produced that released nitroglycerin at a constant rate of about 0.5 mg / cm ~ 2 for 24 hours. This ointment has gained widespread acceptance, but has also raised the issue of whether they can maintain a stable plasma concentration of 24 hours, whether they are clinically relevant and tolerable during this period.