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近十余年来肌酸磷酸激酶(CPK)的升高曾被应用于帮助诊断一些肌病。最近Horano等报告假肥大型和肢体胛带型肌营养不良症病人有血清丙酮酸激酶(PK)的升高;PK可比正常对照者增高28倍,他们的材料提示PK试验可能比CPK更为敏感。本文对29例假肥大型肌营养不良症,12例肌强直性营养不良症和10例面肩肱型肌营养不良症,26例假肥大型带病者以及35例无神经肌肉疾病的对照者所测定的血清PK和CPK结果作了比较。
In the past decade, elevated creatine phosphokinase (CPK) has been used to help diagnose some myopathy. Horano et al recently reported elevated serum levels of pyruvate kinase (PK) in patients with hypertrophic and glenohough muscular dystrophy; PK was 28-fold more potent than the normal controls and their data suggested that PK may be more sensitive than CPK . In this paper, 29 cases of Duchenne muscular dystrophy, 12 cases of myotonic dystrophy and 10 cases of face and shoulder-humeral muscular dystrophy, 26 cases of fecal hypertrophic and 35 cases of neuromuscular diseases were measured Serum PK and CPK results were compared.