C- MPL 及其配体 TPO的作用最初被认为局限于巨核细胞系 ,主要调节巨核细胞和血小板生成。近来发现 TPO不仅作为单因子促进原始造血祖细胞的存活 ,还能通过缩短细胞循环所需的时间加速依赖 IL - 3的祖细胞的生长 ,TPO与 SF或 IL - 3协同则能活化早期多能造血祖细胞。这些发现表 The role of C-MPL and its ligand, TPO, was initially thought to be restricted to megakaryocytic lines that mainly regulate megakaryocyte and platelet production. Recently, TPO not only promoted the survival of primitive hematopoietic progenitor cells as a single factor, but also accelerated the growth of IL - 3 - dependent progenitor cells by shortening the time required for cell cycle. TPO, in combination with SF or IL - 3, activated early pluripotent Hematopoietic progenitor cells. These findings table