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目的:了解5年来国家级监测点出生缺陷的变化趋势、分布情况、畸形种类及相关影响因素,探讨出生缺陷干预措施,进一步提高出生人口素质。方法:对2001年1月～2005年12月在江苏省17所医疗保健机构住院分娩的孕28周～产后7天的150 109例围产儿进行出生缺陷监测,统计分析各种出生缺陷的发生率、类别及相关危险因素。结果:17个国家级监测点出生缺陷发生率120.25/万(1 805/150 109),出生缺陷前3位高发种类是先天性心脏病、总唇裂、多指(趾);男性出生缺陷发生率高于女性;产母≥30岁年龄组出生缺陷发生率高于<30岁年龄组。结论:加强全省孕前及早孕期检查和优生宣教,进一步深入全面开展产前诊断工作,提高干预措施的实施质量,降低出生缺陷发生率。
OBJECTIVE: To understand the changing trend, distribution, types of deformities and related influencing factors of birth defects at national monitoring sites over the past five years, and to explore intervention measures for birth defects to further improve the quality of the birth population. Methods: From January 2001 to December 2005, 150 109 perinatal infants born in 17 medical institutions in Jiangsu Province from 28 weeks pregnant to 7 days postpartum were monitored for birth defects. The incidence of various birth defects were statistically analyzed , Category and related risk factors. Results: The incidence of birth defects in 17 national-level monitoring sites was 120.25 / 10000 (1 805/150 109). The top 3 birth defects were congenital heart disease, total cleft lip and multiple fingers; incidence of male birth defects Higher than that of women. The incidence of birth defects in mother ≥30 years old group was higher than that in <30 years old group. Conclusion: To strengthen prenatal and early pregnancy examination and prenatal education in the province to further carry out prenatal diagnosis in-depth, improve the quality of interventions and reduce the incidence of birth defects.