Nn 6-甲基腺嘌呤(mn 6A)甲基化修饰即RNA腺嘌呤第6位氮原子的甲基化，这一动态过程由编码器、消码器、读码器共同调控。越来越多研究表明mn 6A甲基化修饰影响消化系统肿瘤发生发展的多个环节如增殖、侵袭、转移、耐药等。对mn 6A甲基化修饰在消化系统肿瘤中所扮演角色的深入了解将有助于新型精准诊疗策略的建立进而改善患者的总体预后。n “,”Nn 6-methyladenosine (mn 6A) methylation modification is defined as the methylation at the Nn 6 position of adenosine. This dynamic process is regulated by writer, eraser and reader. Accumulating evidence indicates that mn 6A methylation modification is involved in the initiation and development of various digestive system neoplasms including proliferation, invasion, metastasis and chemoresistance. A further understanding about the role of mn 6A methylation modification in digestive system neoplasms will benefit the development of a novel precise diagnostic and therapeutic strategy and finally improve the overall prognosis of patients.n