目的　观察Ⅰb2～Ⅱb期宫颈癌术前单疗程化疗的近期疗效和不良反应。方法　对 33例Ⅰb2～Ⅱb期宫颈癌进行术前单疗程化疗配合手术和放疗 ,并进行临床分析。结果　化疗结束后 1 0d左右宫颈和阴道病灶完全消失、手术后病理证实镜下无病灶残留者 3例。宫颈和阴道病灶完全消失、手术后病理证实镜下有病灶残留者 6例。化疗后宫颈阴道病灶缩小 5 0 %以上者 1 3例。化疗前后病灶无明显变化者 1 1例。 6例Ⅱb期患者化疗后有 4例病灶缩小 5 0 %以上 ,子宫活动度增大 ,进入手术治疗程序。 2例患者病灶无明显变化 ,进入放疗程序。结论　宫颈癌术前单疗程化疗的近期疗效比较明显 ,无严重的不良反应 Objective To observe the short-term curative effect and adverse reactions of preoperative single-course chemotherapy for stage Ⅰb2 ~ Ⅱb cervical cancer. Methods A total of 33 cases of stage Ⅰ b2 ~ Ⅱb cervical cancer with preoperative single-course chemotherapy combined with surgery and radiotherapy, and clinical analysis. Results About 10 days after chemotherapy, cervical and vaginal lesions disappeared completely, 3 cases were confirmed by pathology after operation. Cervical and vaginal lesions completely disappeared, pathologically confirmed after surgery, there were 6 cases of residual lesions. Cervical vaginal lesions after chemotherapy reduced 50% or more 13 cases. Eleven patients had no obvious change before and after chemotherapy. In 6 patients with stage Ⅱb disease, 4 lesions were reduced by more than 50% after chemotherapy, and the activity of the uterus increased to enter the surgical treatment program. No significant changes in 2 patients with lesions into radiotherapy procedures. Conclusions The short-term curative effect of preoperative single-course chemotherapy for cervical cancer is obvious with no serious adverse reactions