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Objective To evaluate the variation of serum activin A level in liver cirrhotic patients.Methods 83 liver cirrhotic patients (32 Child-Pugh A, 30 Child-Pugh B and 21 Child-Push C) and 32 normal subjects entered the study. The serum levels of activin A, procollagen Ⅲ peptide and collagen Ⅳ were measured by ELISA. Results Compared with those of normal subjects (0. 76±0. 31ng/ml) ,the serum activin A levels were significantly increased in liver cirrhotic patients(1. 33±0. 83ng/ml, P <0. 01). The levels were higher in Child-Pugh C (1. 45±0. 39ng/ml, P <0. 01) and B( 1. 47±0. 81ng/ml, P <0. 01) than in Child-Pugh A (1.00±0. 35 ng/ml) and normal control group(0. 76±0. 31ng/ml). There was no significant difference between Child-Pugh B and C patients or between Child-Pugh A patients and normal control. In corresponding Child-Pugh grades, the serum activin A levels of those suffering from hepatic encephalopathy, digestive tract hemorrhage, infection or ascites were not different from those without such c
Objective To evaluate the variation of serum activin A level in liver cirrhotic patients. Methods 83 liver cirrhotic patients (32 Child-Pugh A, 30 Child-Pugh B and 21 Child-Push C) and 32 normal subjects entered the study. The serum levels of activin A, procollagen III peptide and collagen IV were measured by ELISA. Results of these of normal subjects (0.76 ± 0.31 ng / ml), the serum activin A levels were significantly increased in liver cirrhotic patients (1.33 ± 0.83ng / ml, P <0.01). The levels were higher in Child-Pugh C (1.45 ± 0.39ng / ml, P <0.01) and B / ml, P <0.01) than in Child-Pugh A (1.00 ± 0.35 ng / ml) and normal control group (0.76 ± 0.31 ng / ml). There was no significant difference between Child-Pugh B and C patients or between Child-Pugh A patients and normal control. In the corresponding Child-Pugh grades, the serum activin A levels of those suffering from hepatic encephalopathy, digestive tract hemorrhage, infection or ascites were not different from those without such c