Aim:To evaluate the phytochemical constituents and the aphrodisiac potential of the aqueous extract of Fadogiaagrestis (Rubiaceae) stem in male albino rats.Methods:The aqueous stem extract of the plant was screened forphytochemical constituents.Male rats were orally dosed with 18 mg/kg,50 mg/kg and 100 mg/kg body weight,respectively,of the extract at 24 h intervals and their sexual behavior parameters and serum testosterone concentra-tion were evaluated at days 1,3 and 5.Results:Phytochemical screening revealed the presence of alkaloids andsaponins while anthraquinones and flavonoids are weakly present.All the doses resulted in significant increase inmount frequency,intromission frequency and significantly prolonged the ejaculatory latency (P<0.05) and reducedmount and intromission latency (P<0.05).There was also a significant increase in serum testosterone concentrationsin all the groups in a manner suggestive of dose-dependence (P<0.05).Conclusion:The aqueous extract ofFadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible forits aphrodisiac effects and various masculine behaviors.It may be used to modify impaired sexual functions inanimals,especially those arising from hypotestosteronemia.(Asian J Androl 2005 Dec;7:399-404) Aim:To evaluate the phytochemical constituents and the aphrodisiac potential of the aqueous extract of Fadogiaagrestis (Rubiaceae) stem in male albino rats.Methods:The aqueous stem extract of the plant was screened forphytochemical constituents.Male rats were orally dosed with 18 mg/kg ,50 mg/kg and 100 mg/kg body weight,respectively,of the extract at 24 h intervals and their sexual behavior parameters and serum testosterone concentra tion were evaluated at days 1,3 and 5.Results:Phytochemical screening revealed the presence Of alkaloids and saponins while anthraquinones and flavonoids are weakly present.All the doses yield in significant increase inmount frequency, intromission frequency and significantly prolonged the ejaculatory latency (P<0.05) and reducedmount and intromission latency (P<0.05).There was also a significant Increase in serum testosterone concentrationsin all the groups in a look of suggestive dose-dependence (P<0.05).Conclusion:The aqueous extract ofFadogia agrest Is stem increased the blood testosterone concentrations and this may be the mechanism responsible forits aphrodisiac effects and various masculine behaviors.It may be used to modify impaired sexual functions inanimals,especially those arising from hypotestosteronemia. (Asian J Androl 2005 Dec;7:399- 404)