转化生长因子 β(TGF β)是一种在人体内大部分组织和器官中均有广泛表达的细胞因子 ,并具有多种生物学效应 ,但TGF βmRNA、TGF β和TGF β生物学效应的表达三者之间并不一致。许多研究表明 ,在TGF βmRNA转录、转录后、TGF β蛋白的分泌、释放及与其受体的结合等环节均受到周围环境诸多因素的调控 ,故TGF β的表达与调控的多样性与其生物学效应的发挥存在密切的联系 Transforming growth factor β (TGFβ) is a cytokine that is widely expressed in most tissues and organs of the human body and has a variety of biological effects, but the biological effects of TGFβ mRNA, TGFβ and TGFβ The three are not consistent. Many studies show that the TGFβ mRNA transcription and transcription, TGFβ protein secretion, release and binding with its receptors and other links are subject to many factors in the surrounding environment, so the expression and regulation of TGF β diversity and its biological effects There is a close relationship between the play