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目的:了解我院抗菌药物所致药品不良反应(ADR)发生的特点,为临床合理使用抗菌药物提供参考。方法:对我院2011-2013年上报的159例抗菌药物致ADR报告,按患者的性别及年龄、科室分布、给药途径、涉及药品种类、联合用药情况、ADR累及器官/系统及临床表现等进行回顾性统计、分析。结果:0~10岁患儿和>60岁老年患者ADR发生率最高,分别占23.90%、34.59%;抗菌药物静脉给药途径ADR发生率最高,占86.16%;头孢菌素类药物发生的ADR最多,占30.82%;联合用药致ADR高达31.45%;抗菌药物所致ADR主要累及皮肤及其附件损害,占32.08%。结论:医疗机构应加强抗菌药物ADR的报告和监测工作,确保患者用药安全。
Objective: To understand the characteristics of drug-induced adverse drug reaction (ADR) in our hospital and provide a reference for the rational use of antimicrobial agents in clinic. Methods: A total of 159 cases of ADRs reported in our hospital from 2011 to 2013 were analyzed according to their gender and age, departmental distribution, route of administration, types of drugs involved, combination therapy, ADR involved organ / system and clinical manifestations Retrospective statistics, analysis. Results: The incidence of ADR was the highest in children aged 0 ~ 10 years and elderly> 60 years old, accounting for 23.90% and 34.59% respectively. The incidence of ADR was highest in intravenous antibiotics (86.16%). The incidence of cephalosporins Up to 30.82%. ADR in combination therapy was as high as 31.45%. ADR caused by antibacterials mainly impaired the skin and its appendages, accounting for 32.08%. Conclusion: Medical institutions should strengthen the reporting and monitoring of antimicrobial agents ADR to ensure the safety of patients.