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在 HBsAg 阳性慢性肝病患者中,阿糖腺甙(ARA-A)可抑制病毒复制,在少数患者中,这种作用是持久的。因连续静脉输注的需要,限制了 ARA-A 的效用。一磷酸阿糖腺甙(ARA-AMP)是一种高度水溶性衍化物,可以静脉或肌肉注射。最初对6例男性 HBsAg 阳性慢性肝病患者静脉或肌肉注射 ARA-AMP 10～15mg/kg/日,治疗7～14天。治疗期间乙型肝炎病毒 DNA 聚合酶活性暂时降低,血清病毒 DNA 减少。每12小时注射1次与每6小时注射1次同样有效,但是,每天注射1次无
In patients with HBsAg-positive chronic liver disease, adenosine (ARA-A) inhibits viral replication and in a minority of patients this effect is permanent. The need for continuous intravenous infusion limits the utility of ARA-A. Arathionin monophosphate (ARA-AMP) is a highly water-soluble derivative that can be injected intravenously or intramuscularly. Initially 6 cases of male HBsAg-positive chronic liver disease patients intravenously or intramuscular injection of ARA-AMP 10 ~ 15mg / kg / day for 7 to 14 days. Hepatitis B virus DNA polymerase activity temporarily decreased during treatment, serum viral DNA decreased. It is equally effective to inject once every 12 hours and once every 6 hours, however, once daily