TGF- β家族通过调节靶基因的表达发挥作用 ,其细胞内信号转导通路是 TGF- β的膜受体与靶基因之间的桥梁。TGF- β信号转导的调控是多层次、多水平的。凡能够调控以上信号转导过程中蛋白质 -蛋白质和蛋白质- DNA相互作用的因子就能在各个环节上影响 TGF- β家族的信号转导 ,从而产生多种多样的生物学效应 The TGF-β family plays a role by regulating the expression of the target gene, and its intracellular signal transduction pathway is a bridge between the membrane receptor of TGF-β and the target gene. Regulation of TGF-β signaling is multi-level, multi-level. Where can regulate the above signal transduction protein-protein and protein-DNA interaction of the factors that can affect the TGF-β family in various aspects of signal transduction, resulting in a variety of biological effects