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糖广泛存在于自然界中,与蛋白质和核酸一起并列构成生命体的三大物质单元。由于糖含有多个羟基,含硼酸基的有机物与二醇间有强烈结合作用,故硼酸基团常用于糖类识别和细胞标记。当荧光体与硼酸基团相连接时即可构建识别糖的荧光传感器。本文按发光团结构进行分类,分为:萘基硼酸类受体(包括对二甲氨基萘硼酸衍生物,N-取代的氨基萘硼酸衍生物,1,8-萘二甲酰亚胺为母体的单硼酸衍生物)、杂环硼酸类受体(包括含氮杂环硼酸衍生物、含硫杂环硼酸衍生物以及含氧杂环硼酸衍生物)、蒽环硼酸类受体、芘环硼酸类受体、紫精硼酸类受体及其它类型的硼酸类受体等,详细评述了自2002年以来含硼酸基团的新型荧光受体在单糖识别研究中的最新进展。
Sugar widely exists in nature, together with the protein and nucleic acid constitute the living body of the three material units. Boronic acid groups are commonly used for carbohydrate recognition and cell labeling due to the strong binding of sugar to the organic compounds containing boronic acid groups and diols due to the sugar’s multiple hydroxyl groups. Fluorescent sensors that recognize sugars can be constructed when the phosphor is attached to a boronic acid group. In this paper, the structure of the luminophore classification, divided into: naphthyl boronic acid receptors (including p-dimethylaminonaphthalene boronic acid derivatives, N-substituted aminonaphthalene boronic acid derivatives, 1,8-naphthalimide as the parent ), Heterocyclic boronic acid receptors (including nitrogen-containing heterocyclic boronic acid derivatives, sulfur-containing heterocyclic boronic acid derivatives and oxygen-containing heterocyclic boronic acid derivatives), anthracycline boronic acid receptors, pyrene boronic acids The recent progress in the study of monosaccharide recognition of novel fluorescent acceptors containing boronic acid groups since 2002 has been reviewed in detail.