气管乳头状瘤是一种呼吸系统良性肿瘤,临床虽少见,但近年来报道日渐增多。而其同时合并异时性食管-胃多原发癌临床尚未见报道。据目前研究,气管乳头状瘤发生主要与人乳头状瘤病毒(HPV)感染有关[1-2],另有研究称HPV可能是食管-胃多原发癌的共同相关致病危险因素[3],故HPV感染可能是本例患者罹患多源性肿瘤的一个共同致病因素。目前对于上消化道肿瘤很少有人把HPV当 Tracheal papilloma is a benign respiratory system, although clinically rare, but reported increasing in recent years. However, at the same time, it has not been reported that heterotopic esophageal-gastric multiple primary cancers have been combined. According to the current study, the occurrence of tracheal papilloma mainly associated with human papillomavirus (HPV) infection [1-2], while another study said that HPV may be esophageal-gastric multiple primary cancer associated risk factors [3 ], HPV infection may be a common causative agent of multi-tumor in this patient. Currently, few people use HPV for upper gastrointestinal cancer