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目的：调查深部真菌感染的发病率、常见菌种、好发部位，分析危险因素。方法：对我院１９９８年１月～１０月１３０例住院过程中发生深部真菌感染的患者的临床资料进行分析。结果：深部真菌感染发生率为０．４６％，占医院感染的１５．２１％，好发于呼吸道（占７３．３３％），消化道（占１５．５６％），泌尿道（占８．４６％）等部位，菌种以白色念珠菌最多（占３７．９７％），１３０例均有严重的基础疾病，部分患者大量使用广谱抗生素、免疫抑制剂，或接受过多种侵入性操作。结论：控制医院深部真菌感染至关重要，合理使用抗生素及免疫抑制剂，减少不必要的诊疗操作，早发现、早诊断、早治疗是预防深部真菌感染及改善预后的重要手段。
OBJECTIVE: To investigate the incidence of deep fungal infections, common bacterial species, predilection sites, and analysis of risk factors. Methods: The clinical data of 130 patients with deep fungal infection during hospitalization from January 1998 to October 1998 in our hospital were analyzed. Results: The incidence rate of deep fungal infection was 0.46%, accounting for 15.21% of all nosocomial infections, including respiratory tract (73.33%), digestive tract (15.56%) and urinary tract (8%). 46%). Candida albicans was the most common in the strains (37.97%). All of the 130 patients had severe underlying diseases. Some patients used extensively antibiotics, immunosuppressive drugs or received many invasive procedures . Conclusion: It is very important to control deep fungal infection in hospital. It is necessary to use antibiotics and immunosuppressive agents reasonably to reduce unnecessary diagnosis and treatment. Early detection, early diagnosis and early treatment are important measures to prevent deep fungal infection and improve prognosis.