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目的 :评价大剂量醛氢叶酸 +5FU持续滴注 48小时 (双周疗法 )治疗晚期大肠癌的客观疗效及毒副反应。方法 :本临床研究采用大剂量醛氢叶酸 +5FU持续滴注 48小时 ,每两周重复一次 (双周疗法 )的方案治疗5 2例晚期大肠癌病人 ,所有病人均接受 4疗程化疗。结果 :CR 2例 ,PR 15例 ,NC 18例 ,PD 17例 ,有效率为32 6 9%。病人的主要毒副反应为外周静脉炎、粘膜炎、腹泻、恶心和呕吐、骨髓抑制、脱发等。除外周静脉炎较严重外 ,其余毒性均为Ⅰ～Ⅱ度 ,病人耐受良好。结论 :大剂量醛氢叶酸 +5FU持续滴注 48小时 (双周疗法 )治疗晚期大肠癌疗效较好 ,方案是安全的 ,病人耐受性良好 ,值得在临床上推广使用。
Objective: To evaluate the objective efficacy and toxicity of high-dose aldosterone +5FU continuous instillation for 48 hours (biweekly therapy) for advanced colorectal cancer. Methods: In this clinical study, high-dose aldosterone +5FU was continuously instilled for 48 hours, biweekly (bi-weekly therapy) regimens were used to treat 52 patients with advanced colorectal cancer, and all patients received 4 courses of chemotherapy. Results: There were 2 CR patients, 15 PR patients, 18 NC patients, and 17 PD patients. The effective rate was 32 69%. The main toxicities and side effects of patients are peripheral phlebitis, mucositis, diarrhea, nausea and vomiting, bone marrow suppression, and hair loss. With the exception of severe peripheral phlebitis, the remaining toxicity was I to II degrees and the patient was well tolerated. Conclusion : High-dose aldosterone +5FU continuous instillation for 48 hours (biweekly therapy) is effective for the treatment of advanced colorectal cancer. The protocol is safe and well tolerated. It is worthy of promotion in clinical practice.