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目的 观察硅油充填眼晶状体前囊膜及上皮细胞的病理学改变及 Caspase- 3表达 ,探讨硅油引起白内障的病因及与凋亡的关系。方法 收集 2 7只晶状体前囊膜 ,通过HE染色和免疫组化方法对硅油眼的晶状体前囊膜和上皮细胞及 Caspase- 3在其上的表达进行观察。结果 前囊膜下许多空间被硅油滴占据 ;Caspase- 3在晶状体上皮细胞有很好的表达 ,2 7例中有 2 3例呈阳性表达。结论 硅油滴与白内障的发生、发展有关 ;凋亡在硅油眼并发白内障中存在
Objective To observe the pathological changes and the expression of Caspase-3 in anterior capsule and epithelium of silicone oil-filled lens and explore the relationship between apoptosis and the etiology of silicone oil-induced cataract. Methods Twenty-seven anterior lens capsular membranes were collected and the expression of anterior lens capsule and epithelial cells and Caspase-3 in silicone oil eyes were observed by HE staining and immunohistochemistry. Results The anterior capsule was occupied by silicone oil droplets. Caspase-3 was well expressed in lens epithelial cells, and 23 of 27 cases were positive. Conclusion Silicone oil droplets are associated with the occurrence and development of cataract. Apoptosis is present in silicone oil eyes with cataract