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观察肝硬化患者红细胞变形性 (ED)、红细胞能量代谢和血氧变化。以红细胞ATP和 2 3-二磷酸甘油酸 (2 3-DPG)含量作为衡量红细胞能量代谢状态的指标 ,对 32例肝硬化患者取血动态观察其ED、ATP和 2 3-DPG含量、PaO2 和SaO2 的变化并与正常人比较。肝硬化患者的ED、PaO2 和SaO2 明显降低 ,2 3-DPG含量明显增高 ;并发肝性脑病 (HE)时PaO2 明显降低 ,ATP及 2 3-DPG含量明显减少。肝硬化患者的ED明显降低并伴有低氧血症 ;红细胞能量代谢降低与HE的发生有关。
Erythrocyte deformability (ED), erythrocyte energy metabolism and blood oxygen changes were observed in patients with cirrhosis. Using erythrocytes ATP and 2 3-DPG (2 3-DPG) content as indicators of erythrocyte energy metabolism, 32 patients with cirrhosis were collected to observe the levels of ED, ATP and 2 3-DPG, PaO2 and SaO2 changes and compared with normal people. The levels of ED, PaO2 and SaO2 in cirrhotic patients were significantly decreased, and the levels of 2 3-DPG were significantly increased. PaO2 was significantly decreased and the content of ATP and 2 3-DPG was significantly decreased in patients with hepatic encephalopathy (HE). ED in patients with cirrhosis was significantly reduced and accompanied by hypoxemia; reduced energy metabolism of red blood cells and the occurrence of HE.