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目的观察不同阶段糖尿病肾病患者血清中P-选择素的水平变化,探讨其与糖尿病肾病的相关性。方法健康对照组为50名健康体检者,2型糖尿病患者150例分为正常蛋白尿组、微量白蛋白尿组及临床蛋白尿组,每组各50例。用酶联免疫吸附法检测血清P-选择素。结果所有糖尿病患者血清中P-选择素含量(1 7.36±6.19)ng/ml,均明显高于正常对照组[(7.25±1.69)ng/ml](P<0.01);微量白蛋白尿组[(16.59±3.36)ng/ml]及临床白蛋白尿组[(23.84±5.96)ng/ml]P-选择素又高于正常白蛋白尿组[(12.34±2.31)ng/ml](P<0.01);临床白蛋白尿组又高于微量白蛋白尿组(P<0.01);P-选择素水平与空腹血糖、糖化血红蛋白、高敏C反应蛋白、尿白蛋白均呈正相关(r=0.54,0.68,0.97,0.71,P均<0.01)。结论糖尿病肾病患者血清P-选择素的水平升高,可作为糖尿病肾病的检测指标之一。
Objective To observe the changes of serum P-selectin level in patients with diabetic nephropathy at different stages and to explore its correlation with diabetic nephropathy. Methods Fifty healthy subjects were included in the healthy control group and 150 cases of type 2 diabetes mellitus were divided into normal proteinuria group, microalbuminuria group and clinical proteinuria group, 50 cases in each group. Serum P-selectin was detected by enzyme-linked immunosorbent assay. Results The levels of P-selectin in all diabetics (1 7.36 ± 6.19) ng / ml were significantly higher than those in normal control [(7.25 ± 1.69) ng / ml] (P <0.01) (16.59 ± 3.36) ng / ml] and clinical albuminuria group [(23.84 ± 5.96) ng / ml] P-selectin was higher than that of normal albuminuria group [(12.34 ± 2.31) ng / ml] 0.01). The levels of P-selectin were positively correlated with fasting blood glucose, glycosylated hemoglobin, high-sensitivity C-reactive protein and urinary albumin in clinical albuminuria group (P <0.01) 0.68,0.97,0.71, P <0.01). Conclusion Patients with diabetic nephropathy serum P-selectin levels increased, can be used as one of the indicators of diabetic nephropathy.