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野花椒系芸香科植物(Zanthoxylum simulans Hance),其根皮有止痛及局麻作用。其水溶性生物碱有肌松作用,曾用于外科手术作为中麻辅助用药。常志青从中分离到加钖果宁[(—)edulinine,简称加钖碱,下同],并发现有镇痛及中枢抑制作用。本文进一步证明其镇痛作用及其作用机制与阿片受体有关。
Wild pepper is Rutaceae plants (Zanthoxylum simulans Hance), the root bark has analgesic and local anesthetic effects. Its water-soluble alkaloids have muscle relaxant effect, which was used as a surgical aid for midriff. Chang Zhiqing isolated from the plus 钖 Guoning [(-) edulinine, referred to plus 钖 alkali, the same below] and found to have analgesic and central inhibitory effect. This article further evidence of its analgesic effect and its mechanism of action and opioid receptors.