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雷尼替丁为第二代组胺 H_2—受体拮抗剂,具有比西咪替丁更强效的抑制胃酸分泌的作用,但无后者常见的不良反应,临床上主要用于治疗胃及十二指肠溃疡、应激性胃出血等疾病,疗效显著。本文简述了雷尼替丁与21种药物在肝内代谢等体内过程相互作用的国外研究概况和某些药物相互作用的机制。雷尼替丁对某些治疗指数狭窄药物的体内过程的影响,可能导致毒性反应,值得临床重视。
Ranitidine is the second generation of histamine H 2 -receptor antagonist, with a more potent inhibition of gastric acid secretion than cimetidine, but no latter common adverse reactions, clinically mainly for the treatment of stomach and Duodenal ulcer, stress gastric bleeding and other diseases, significant effect. This article briefly reviews the foreign studies and the mechanisms of some drug interactions between ranitidine and 21 drugs in vivo such as intrahepatic metabolism. The effect of ranitidine on the in vivo processes of some narrow-range drugs with therapeutic indices may lead to toxic reactions, deserving clinical attention.