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“钙拮抗剂维拉帕米对离体大鼠心脏缺氧再给氧损伤和在体大鼠心脏缺血再灌注损伤均有预防性保护作用。维拉帕米能显著减少缺血心肌磷酸肌酸激酶释放,降低丙二醛含量和保护超氧化物歧化酶活性。在整体动物心肌缺血再灌注损伤实验,维拉帕米能显著促进缺血心肌前列环素合成。结果表明维拉帕米对心肌缺血再灌注损伤的保护作用与抗脂质过氧化有关,其促进前列环素合成作用可能与其抗心肌缺血有关。
"Verapamil, a calcium antagonist, exerted a preventive effect on reoxygenation injury induced by hypoxia and ischemia-reperfusion injury in isolated rat hearts, and verapamil significantly reduced myocardial phosphorylation Acid kinase release, reduce the content of malondialdehyde and protect superoxide dismutase activity in the whole animal myocardial ischemia-reperfusion injury experiment, verapamil can significantly promote myocardial synthesis of prostacyclin.The results show that verapamil The protective effect of myocardial ischemia-reperfusion injury and anti-lipid peroxidation, and promote the synthesis of prostacyclin may be related to its anti-myocardial ischemia.